AMBRYX LOGO] 11099 N. Torrey Pines Road, Suite 160 La Jolla, CA 92037 Telephone: 858-404-0740 Facsimile: 858-404-0750 February 21, 2000 Dr. Mark J. Zoller 7 Sutton Place Weston, MA 02193 Telephone: 781-894-6190 Dear Mark:

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