EXCLUSIVE RIGHT TO LICENSE AGREEMENT
EXHIBIT
10.1
EXCLUSIVE
RIGHT TO LICENSE AGREEMENT
Oncolin
Therapeutics, Inc. of Houston, Texas would like to evaluate Genistein
analogs and the Pharmaceutical Research Institute ( PRI ) and Xx. Xxxxxx
Xxxxxxxxx would like to have the same analogs evaluated and therefore agree
to
the following terms:
1. Oncolin
Therapeutics will have an exclusive worldwide right to license patents and
patent applications covering composition and/or use of Genistein analogs for
cancer treatment for a period of 9 months from receipt of compounds to be tested
at $4,000.00/patent. If the company requires additional time , Oncolin would
pay
an additional $8,000/patent for a 6 month extension.
2. PRI
will
supply 1-2 of its best compounds for evaluation initially providing 100 mg
quantities for in vitro evaluation and gram quantities of 1-2 compounds for
in
vivo evaluation for a small fee not to exceed $5,000. The results of these
experiments will be provided to PRI.
3. If
Oncolin
desires to license these patents the terms would include :
a) milestones
of $100,000 successful completion of Phase
I/II clinical trial
$400,000
successful completion of Phase
II clinical trial
$900,000
NDA
approval
b) 2.5%
royalty
on sales of product
c) PRI
would
have an exclusive commercial supply agreement to be the principal supplier
(
minimum of 70%) of drug substance and full exclusivity for the European market
provided PRI has an approved GMP facility with the capacity
required.
4.
PRI
asserts
that it has the rights to the patents and patent applications and the right
to
license said IP.
For
Oncolin Therapeutics,
Inc. For
PRI
/s/
Xxxxxx
Xxxxxx /s/ Xxxxxx Xxxxxxxxx
Xxxxxx
Xxxxxx
Xxxxxx Xxxxxxxxx
Date April
1,
2008
Date March 24, 2008
1
Appendix
1
List
of
patents and patent applications pertaining to the exclusive right to license
agreement between PRI, Warsaw and Oncolin, Houston, TX, USA.
1)
|
Isoflavones
and their derivatives in the treatment of mucopolysaccharidoses;
WO
2007/035121 (29 March 2007; text available as pdf
[Eng])
|
2)
|
New
derivatives of genistein and pharmaceutical preparations containing
them;
P-346955 (2001; text available as pdf [Engl
translation])
|
3)
|
Regioselective
functionalization of hydroxyl groups in polyphenolic compounds;
P-354794
(2002, text in Polish)
|
4)
|
New
applications of genistein derivatives; P-369929 (2004, text in
Polish)
|