Amendment #4 Consulting Agreement dated October 17, 2016 between ProMIS Neurosciences, Inc. and Danforth Advisors, LLC

Exhibit 10.12.4

Certain identified information has been excluded from the exhibit pursuant to Item 601(b)(10)(iv) because it is both not material and is the type of information that the registrant treats as private or confidential. Redacted information is indicated by: [***]

Amendment #4

Consulting Agreement dated October 17, 2016 between

ProMIS Neurosciences, Inc. and Xxxxxxxx Advisors, LLC

This Amendment No. 4 to Consulting Agreement (“Amendment”) is made as of October 1, 2021 (“Effective Date”), by and between ProMIS Neurosciences, Inc. (“Company”) and Xxxxxxxx Advisors, LLC (“Consultant” or “Xxxxxxxx”). Capitalized terms used but not defined herein shall have the respective meaning set forth in the Consulting Agreement by and between Xxxxxxxx Advisors and the Company dated as of October 17, 2016 (“Agreement”).

WHEREAS, Xxxxxxxx is engaged by the Company under the terms and conditions of the Consulting Agreement; and

WHEREAS, the Company and Consultant mutually desire to amend the term and scope of the Agreement.

NOW, THEREFORE, in consideration of the premises and the mutual covenants and agreements herein contained and for the other good and valuable consideration, receipt of which is hereby acknowledge, the parties hereby agree as follows:

1. Section 3. Term and Termination is hereby modified to extend the term of the Agreement until October 29, 2024.

2. Exhibit A to the Agreement is hereby modified to allow Xxxxxxxx to add the services of various Xxxxxxxx employees to perform the Services required and approved, such approval to be provided verbally or by email, by the Company at each such Xxxxxxxx employee’s billable rate in effect at the time they are added to the Agreement. The billable rates in effect as of the date of this Amendment No.1 are as described in Exhibit A-4.

3. Except as specifically provided for in this Amendment, the terms of the Agreement shall be unmodified and shall remain in full force and effect.

This Amendment may be executed in one or more counterparts, each of which shall be considered an original instrument, but all of which shall be considered one and the same Amendment, and shall become binding when one or more counterparts have been signed by each of the parties and delivered to the other.

IN WITNESS WHEREOF, this Amendment has been executed by the Company and Xxxxxxxx to be effective as of the date first above written.

XXXXXXXX ADVISORS, LLC			PROMIS NEUROSCIENCES, INC.
By:	/s/ Xxxxx Xxxxxxx		By:
Print Name:      Xxxxx Xxxxxxx			Print Name:      Xxxxxx Xxxxxxxx
Title:   Chief Executive Officer			Title:   Executive Chairman
Date:	11/10/2021		Date:	/s/ Xxxxxx Xxxxxxxx

2

Exhibit A-4

Description of Services and Schedule of Fees

Xxxxxxxx will perform mutually agreed to finance and accounting functions which are necessary to support the management and operations of the Company including, but not limited to, the functions set forth below:

Role		Hourly Rate		Function
Sr. Advisor		$[***]/hour		Senior Advisory
CFO		$[***]/hour		CFO
Sr. Director		$[***]/hour		Principal Accounting Officer
Sr. HR Director		$[***]/hour		Human Resources
HR Director		$[***]/hour		Human Resources
Director		$[***]/hour		VP Finance
Sr HR Manager		$[***]/hour		Human Resources
Sr Manager		$[***]/hour		Sr Controller/FP&A
Manager		$[***]/hour		Controller
HR Manager		$[***]/hour		Human Resources
Sr. Consultant		$[***]/hour		Asst. Controller
Consultant		$[***]/hour		Staff Accountant

Xx. Xxxxxx Xxxxxxx will work for a monthly fixed fee of $15,000 (estimated at a 35 hour commitment /month), commencing October 1, 2021. As additional consideration for the fixed fee arrangement, the Board of Directors of the Company will vote at its next Board Meeting on November 11, 2021 to provide Xxxxxxxx an option (the “Xxxxxxxx Option”) to purchase 500,000 shares of common stock. The Xxxxxxxx Option shall have a 10-year term an exercise price equal to the fair value of the common stock as determined by the Board of Directors of the Company on the date such option is issued and shall vest ratably over 12 months commencing on the Effective Date, subject to the continued provision of services to the Company by Xxxxxxxx as of each vesting date. If this agreement is terminated by the Company within 6 months of the Effective Date, for other than cause, then shares as to 50% of the Xxxxxxxx Option shall vest. The Company and Xxxxxxxx will enter into a separate stock option agreement within 30 days of the Effective Date, to be negotiated in good faith.