April 21, 2011

Exhibit 10.65

April 21, 2011

Durect Corporation

2 Results Way

Cupertino, CA 95014

Attention: Xxxxx X. Xxxxx

Re: Amendment to Commercial Real Estate Lease

Reference is made to that Commercial Real Estate Lease (the “Lease”) entered into by and between EWE, Inc., an Alabama corporation (“LESSOR”) and Durect Corporation, a Delaware corporation, (“ LESSEE”) dated September 21, 2004. All capitalized terms used herein shall have the meaning ascribed to such terms in the Lease.

XXXXXX and XXXXXX hereby agree as follows, effective on the date that both XXXXXX and XXXXXX have executed this Amendment:

The PREMISES set forth in Paragraph I shall be defined as:

Building 0000 Xxxxxx Xxxxxxx, Xxxxxx, Xxxxxxx 00000 only.

The TERM of the Lease set forth in Paragraph 3 shall be extended by four months such that the Lease shall terminate on January 31, 2012 instead of September 30, 2011.

The RENTAL during the extension period from October 1, 2011 to January 31, 2012 shall be $7500.00 per month.

Except as expressly modified above, all remaining terms of the Lease shall remain the same. XXXXXX and XXXXXX have hereunto set or caused to be set their respective signatures and seals on the dates set forth herein.

Sincerely,

/s/ Xxx Xxxxxxx

Vice President, EWE Inc.

AGREED TO BY DURECT
Name:		/s/ Xxxxx. X. Xxxxx
Title:		CEO
Date:		May 23, 2011