EASTVIEW HOLDINGS LLC 777 Old Saw Mill River Road Tarrytown, New York 10591 October 23, 2003

Exhibit 10.27

EASTVIEW HOLDINGS LLC
000 Xxx Xxx Xxxx Xxxxx Xxxx
Xxxxxxxxx, Xxx Xxxx 00000

                                                                            October 23, 2003

BY HAND
Progenics Pharmaceuticals, Inc.
000 Xxx Xxx Xxxx Xxxxx Xxxx
Xxxxxxxxx, Xxx Xxxx 00000
Attention: Mr. Xxxxxx XxXxxxxx

Re: Lease dated as of September 30, 2003 between Eastview Holdings LLC (“Landlord”), and Progenics Pharmaceuticals, Inc. (“Tenant”) for space in the project known as The Landmark at Eastview (the “Lease”)                              

Gentlemen:

     This letter agreement is intended to amend Section 37.1 of the Lease. The date of “October 23, 2003” as set forth in Section 37.1 of the Lease is hereby deemed deleted and replaced with the date “November 24, 2003”.

Very truly yours,

EASTVIEW HOLDINGS LLC

By: EASTVIEW SPE INC, its Managing Member

By:/s/ Xxxxx Xxxxxxxxx

Name: Xxxxx Xxxxxxxxx

Title: Senior Vice President

ACKNOWLEDGED AND AGREED:

PROGENICS PHARMACEUTICALS, INC.

By: /s/ Xxxxxx X. XxXxxxxx
   Xxxxxx X. XxXxxxxx
   Vice President