SECOND AMENDMENT TO EMPLOYMENT AGREEMENT

Exhibit 10.12

SECOND AMENDMENT TO EMPLOYMENT AGREEMENT

This Agreement is made as of the 16^th day of December 2002 between Oragenics, Inc. ("Employer") and Xxxxxxx X. Xxxxxxx ("Employee").

Employer and Employee entered into an Employment Agreement as of the 1^st day fo May, 2002, as amended on the 3^rd day of October, 2002.

Employer and Employer desire to amend the Employment Agreement, as amended, and they hereby agree as follows:

Section 5. Compensation and Reimbursement is hereby amended by replacing the defined payment term, "the initial compensation rate of Ninety Six Thousand Dollars ($96,000) per annum" with the new defined payment term, "the initial compensation rate of One Hundred Twenty Thousand Dollars ($120,000) per annum."

The Employment Agreement, is herein further amended, shall remain in full force and effect and is hereby ratified and confirmed.

ORAGENICS, INC.

By:	/s/ Xxxxx X. Xxxxxxx	/s/ Xxxxxxx X. Xxxxxxx
	Its President	Xxxxxxx X. Xxxxxxx