ContractSeptember 15th, 2020
FiledSeptember 15th, 2020Amendment No. 1 to the Clinical Trial Agreement hereby concluded by and between: Eli Lilly Cork Limited Address: Island House Eastgate Road Eastgate Business Park Little IslandCork IrelandTax identification number: IE3508310BH andNemocnice Na Bulovcewith its Registered Office in: Budínova 67/2, 180 81 Prague 8 - Libeň,Czech RepublicTax identification number: CZ00064211 Represented by: ██████, Deputy for Science, Research, Grant Activities and Development,based on authorization This Clinical Trial Agreement Amendment No.1 (hereinafter “Amendment”) amends the Clinical Trial Agreement related to Protocol J2G-MC-JZJC entitled “LIBRETTO-431: A Multicenter, Randomized, Open-Label, Phase3 Trial Comparing LOXO-292 to Platinum- Based and Pemetrexed Therapy with or without Pembrolizumab as Initial Treatment of Advanced or Metastatic RET Fusion-Positive Non-Small Cell Lung Cancer”, entered into by and between the Parties on March 13, 2020 and became effective on April 8, 2020 (hereinafter “Agreem