December 15, 2023 Confidential Via Electronic Mail James Empfield Dear James, Re: Third Amended and Restated Employment AgreementEmployment Agreement • February 29th, 2024 • Xenon Pharmaceuticals Inc. • Pharmaceutical preparations • Florida
Contract Type FiledFebruary 29th, 2024 Company Industry JurisdictionWe are pleased to offer you this Third Amended and Restated Employment Agreement which replaces and supersedes your earlier Offers of Employment (the “Prior Agreements”) dated February 2016, January 1, 2017 and March 20, 2019 with Xenon Pharmaceuticals USA Inc. (the “Company”), a wholly-owned subsidiary of Xenon Pharmaceuticals Inc. (the “Parent”). You will be credited for all purposes with your service to the Company back to your start date of February 8, 2016, when you were originally employed by Parent. As of December 15, 2023 (the “Effective Date”), you will be permitted to relocate to the State of Florida and continue to be engaged by the Company in the full-time position of Executive Vice President, Drug Discovery, subject to the terms as set forth herein. Subject to Sections L through P below, the Company agrees to employ you, and you agree to serve the Company, on an “at-will” basis, which means that either the Company or you may terminate your employment with the Company at an
Re: Amended and Restated Employment AgreementEmployment Agreement • March 9th, 2020 • Xenon Pharmaceuticals Inc. • Pharmaceutical preparations • Massachusetts
Contract Type FiledMarch 9th, 2020 Company Industry JurisdictionWe are pleased to offer you this Amended and Restated Employment Agreement which replaces and supersedes your earlier Offer of Employment (the “Prior Agreement”) dated January 1, 2017 with Xenon Pharmaceuticals USA Inc. (the “Company”), a wholly-owned subsidiary of Xenon Pharmaceuticals Inc. (the “Parent”). You will be credited for all purposes with your service to the Company back to your start date of February 8, 2016, when you were originally employed by Parent. As of March 20, 2019 (the “Effective Date”), you will continue to be engaged by the Company in the full-time position of SVP, Drug Discovery. Subject to Sections L through P below, the Company agrees to employ you, and you agree to serve the Company, on an “at-will” basis, which means that either the Company or you may terminate your employment with the Company at any time and for any or no reason, in accordance with the terms of this agreement (the “Agreement”).
Re: Amended and Restated Employment Agreement (U.S. Executive)Employment Agreement • March 25th, 2019 • Xenon Pharmaceuticals Inc. • Pharmaceutical preparations • Massachusetts
Contract Type FiledMarch 25th, 2019 Company Industry JurisdictionWe are pleased to offer you this Amended and Restated Employment Agreement which replaces and supersedes your earlier Offer of Employment (the “Prior Agreement”) dated [DATE] with Xenon Pharmaceuticals USA Inc. (the “Company”), a wholly-owned subsidiary of Xenon Pharmaceuticals Inc. (the “Parent”). You will be credited for all purposes with your service to the Company back to your start date of [DATE]. As of [DATE] (the “Effective Date”), you will continue to be engaged by the Company in the full-time position of [TITLE]. Subject to Sections L through P below, the Company agrees to employ you, and you agree to serve the Company, on an “at-will” basis, which means that either the Company or you may terminate your employment with the Company at any time and for any or no reason, in accordance with the terms of this agreement (the “Agreement”).
Re: Amended and Restated Employment AgreementEmployment Agreement • March 25th, 2019 • Xenon Pharmaceuticals Inc. • Pharmaceutical preparations • Massachusetts
Contract Type FiledMarch 25th, 2019 Company Industry JurisdictionWe are pleased to offer you this Amended and Restated Employment Agreement which replaces and supersedes your earlier Offer of Employment (the “Prior Agreement”) dated February 21, 2018 with Xenon Pharmaceuticals USA Inc. (the “Company”), a wholly-owned subsidiary of Xenon Pharmaceuticals Inc. (the “Parent”). You will be credited for all purposes with your service to the Company back to your start date of March 19, 2018. As of March 19, 2019 (the “Effective Date”), you will continue to be engaged by the Company in the full-time position of Chief Medical Officer. Subject to Sections L through P below, the Company agrees to employ you, and you agree to serve the Company, on an “at-will” basis, which means that either the Company or you may terminate your employment with the Company at any time and for any or no reason, in accordance with the terms of this agreement (the “Agreement”).