INVESTIGATOR’S AGREEMENTInvestigator Agreement • July 28th, 2023
Contract Type FiledJuly 28th, 2023Abbreviation Definition AE adverse event ALT alanine transaminase ANC absolute neutrophil count ARC absolute reticulocyte count AST aspartate transaminase AUC area under the concentration-time curve BID twice daily BIW biweekly BOR best overall response BP blood pressure BSA body surface area BUN blood urea nitrogen C cycle CEA carcinoembryonic antigen CFR Code of Federal Regulations CI confidence interval Cmax maximum plasma concentration CONSORT Consolidated Standards of Reporting Trials CPI checkpoint inhibitor CR complete response CRC colorectal cancer CrCl creatinine clearance CT computed tomography CTCAE Common Terminology Criteria for Adverse Events CYP3A cytochrome P450 3A D day DCR disease control rate DLBCL diffuse large B-cell lymphoma dMMR deficient mismatch repair DNA deoxyribonucleic acid DOR duration of response