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Observational Study Agreement XXXX Protocol • July 3rd, 2020

OBSERVATIONAL STUDY AGREEMENT XXXX Protocol # XXXXX This Observational Study Agreement (“Agreement”) between Value Outcomes s.r.o., a a company established under the laws of the Czech Republic with a place of business at Václavská 316/12, Nové Město (Prague 2), 120 00 Prague, CzechRepublic, Identification Number: 27079333, registered in the Commercial Register maintained by the Municipal Court in Prague, Section C, File 9469 (“CRO”) and Thomayerova nemocnicewith a place of business at Vídeňská 800, 140 59 Praha 4 - Krč, Česká republikaIČO: 00064190 DIČ: CZ00064190state contributory organizations established by the Ministry of Healthcare MZDR 17268-IV/2012, registered in the Commercial Register at the Municipal Court in Prague, section Pr, vl. 1043 represented by: doc. MUDr. Zdeněk Beneš, CSc., Director (“Institution”), and XXXXXXX, with a place of work or business at Vídeňská 800, 140 59 Praha 4 - Krč, Czech republic (“Principal Investigator”), when signed by all parties, is effective

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