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Clinical Trial Agreement • June 21st, 2021

CLINICAL TRIAL AGREEMENT This Clinical Trial Agreement (“Agreement”) is executed as of the date of last signature (“Validity Date”) The effectiveness of the contract is subject to the publication of the contract in the register of contracts, a public administration information system in which contracts concluded by entities specified in Act No. 340/2015 Coll., as amended ("Effective Date") are published, by and among: Covance Inc., located at 206 Carnegie Center, Princeton, NJ 08540, USA (Tax ID No.: 22-3265977), represented byand its affiliates (“Covance” or “CRO”) ; and Fakultní nemocnicí Hradec Králové, Sokolská 581, 500 05 Hradec Králové – Nový Hradec Králové, Czech republic, represented by prof. MUDr. Vladimírem Paličkou, CSc., dr. h. c., director, Tax ID Nr. CZ00179906,(hereinafter referred to as “Institution”) and IV. Interní hematologická klinika, Fakultní nemocnice Hradec Králové, Sokolská 581,500 05 Hradec Králové– Nový Hradec Králové, Česká republika, (hereinafter referred t

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