Common Contracts

AMENDMENT NO. 1 TO At-THE-market issuance SALES AGREEMENT May 7, 2018 Ladies and Gentlemen:

At-the-Market Issuance Sales Agreement • May 5th, 2020 • New York

• Contract Type
  At-the-Market Issuance Sales Agreement
• Filed
  May 5th, 2020
• Jurisdiction
  New York

Synthetic Biologics, Inc. (the “Company”) and FBR Capital Markets & Co. (“FBR”) are parties to that certain At-the-Market Issuance Sales Agreement dated August 5, 2016 (the “Original Agreement”). All capitalized terms not defined herein shall have the meanings ascribed to them in the Original Agreement. The parties, together with B. Riley FBR, Inc. (“B. Riley FBR”), intending to be legally bound, hereby amend the Original Agreement as follows:

AMENDMENT NO. 1 TO At-THE-market issuance SALES AGREEMENT

At-the-Market Issuance Sales Agreement • May 7th, 2018 • Synthetic Biologics, Inc. • Pharmaceutical preparations • New York

• Contract Type
  At-the-Market Issuance Sales Agreement
• Filed
  May 7th, 2018
• Company
  Synthetic Biologics, Inc.
• Industry
  Pharmaceutical preparations
• Jurisdiction
  New York

Synthetic Biologics, Inc. (the “Company”) and FBR Capital Markets & Co. (“FBR”) are parties to that certain At-the-Market Issuance Sales Agreement dated August 5, 2016 (the “Original Agreement”). All capitalized terms not defined herein shall have the meanings ascribed to them in the Original Agreement. The parties, together with B. Riley FBR, Inc. (“B. Riley FBR”), intending to be legally bound, hereby amend the Original Agreement as follows: