Common Contracts
1 similar Thesis contracts
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of LeidenThesis • July 22nd, 2008
This thesis is focused on the role and interaction of different cholesterol and phospholipid transporters. Cholesterol homeostasis is accomplished via a tightly regulated balance between the intake of dietary cholesterol and de novo cholesterol synthesis. A disruption in the cholesterol homeostasis can result in changed plasma cholesterol levels and a modulated risk for the development of cardiovascular disease. Plasma cholesterol levels are the consequence of the complex interaction of gene expression in the liver and peripheral tissues, such as macrophages in the vascular wall.
