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Observational Study Agreement • December 29th, 2016

OBSERVATIONAL STUDY AGREEMENT SMLOUVA O PROVÁDĚNÍ OBSERVAČNÍSTUDIE This Observational Study Agreement (the “Agreement”), is made as of the Effective Date (as defined below), by and between Biogen Idec Research Limited with a place of business at Innovation House, 70, Norden Road, Maidenhead, Berkshire, SL6 4AY, United Kingdom (“Biogen”), Nemocnice Pardubického kraje, a.s., located at Kyjevská 44, 532 03 Pardubice, Czech Republic, represented by MUDr. Tomáš Gottvald - Chairperson of the Board of Directors, MUDr. Vladimír Ninger, Ph.D. – Member of the Board of Directors, listed in the Commercial Register at the Municipal Court of Hradec Králové, section B, insert 2629, Company ID no.: 27520536, Tax ID no: CZ27520536 (the “Institution”), MUDr. Alena Novotná, located at Komenského 103, Pardubice530 03, Czech Republic (the “Physician”) and Quintiles Czech Republic, s.r.o., Praha 5, Jinonice, Radlická 714/113a, 158 00, Czech Republic, Identification Number: 247 68 651, Tax identification Num

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