Shared Care GuidelineShared Care Guideline • July 31st, 2020
Contract Type FiledJuly 31st, 2020Azithromycin long term use in chronic obstructivepulmonary disease (COPD) Introduction This shared care agreement outlines the responsibilities between the specialist and the generalist for managing the prescribing of azithromycin for indications listed above. Indication This is an ‘off-label’ use for azithromycin. Dosage and administration Azithromycin 500 mg three times a week. A starting dose of azithromycin 250mg three times a week can be used to minimise side effect risk with titration to clinical response. (usually Mon, Wed, Fri) Contraindications and cautions • LFTs > 2x upper limit of normal• Atypical mycobacterial infection (treat active infection before starting)• Allergy to azithromycin or erythromycin or any macrolide• Use with caution in patients on digoxin and avoid co prescribing with drugs known to prolong QT interval on ECG• Only to be used in pregnancy if the benefit outweighs the risk• Not to be used whilst breastfeeding• Macrolide monotherapy should be avoided