Common Contracts
1 similar Distribution Agreement contracts
Distribution AgreementDistribution Agreement • April 22nd, 2011
group was also investigated. With this modification, there are four stereoisomers of each tamoxifen analog: R1S2, R1R2, S1S2 and S1R2. In order to keep the two short phenyl side chains in a trans-orientation, only R1S2 and S1R2 isomers were investigated. In this series, analog 3-15 with Cl at R1 and cyclohexane at region III (the R1S2 isomer in Figure 3.9 c, shown as green sticks) presents a pose with slight H12 steric conflicts. The cyclopropyl retains the same position as the double bond in the parent compound. But when R1 is replaced by OMe in the R1S2 isomer (analog 3-16 in Figure 3.9 c, shown as yellow sticks), it retains almost the same pose as the double bond form. But if R1 is replaced by Et (analog 3-17 shown in Figure 3.9 d), the head group in the top-scoring pose approaches tunnel A instead of the H12 region. However, in this pose the hydroxyl group has steric conflicts with H12 instead. This pose is similar to the top-scoring pose of the R1S2 analog with Cl substitution at
