Clinical Trial Agreement – Tripartite – EEA Protocol No. CGT-9486-21-301 (PEAK) FinalClinical Trial Agreement • August 16th, 2023
Contract Type FiledAugust 16th, 2023CLINICAL TRIAL AGREEMENT SMLOUVA O PROVEDENÍ KLINICKÉHO HODNOCENÍ THIS CLINICAL TRIAL AGREEMENT(together with Attachments A and B, the “Agreement”) among Cogent Biosciences, Inc, a United States Delaware corporation with an office at 275 Wyman Street, 3rd Floor, Waltham, MA 02451, USA (“Sponsor” or “Cogent”) and Fakultní nemocnice Hradec Králové, with an address at Sokolská 581, 500 05 Hradec Králové– Nový Hradec Králové, Czech Republic (“Institution”) and with an address at Fakultní nemocnice Hradec Králové, Klinika onkologie a radioterapie, Sokolská 581, 500 05 Hradec Králové – Nový Hradec Králové, Czech Republic (“Investigator”) when signed by all parties, is valid as of the date of last signature and effective on the day of publication in the Register of contracts (the “Effective Date”). Cogent is the sponsor of a multi-center clinical trial of bezuclastinib, or CGT9486, (the “Trial Drug”) under protocol number CGT9486-21-301 entitled “(Peak) A Phase 3 Randomized, Open- Label, Mu