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License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of LeidenResearch Publication • October 28th, 2008
In the phytochemistry from Cannabis sativa L., six secondary metabolite groups (cannabinois, flavonoids, stilbenoids, terpenoids, alkaloids and lignans) have been identified. Pharmacological aspects of the best known group of the secondary metabolism of this plant, cannabinoids, have been extensively studied. Other studies have been focused on the elucidation of the cannabinoid biosynthetic pathway. Although, it has not been completely elucidated, and the same applies for other secondary group biosynthetic pathways in the plant, it has been suggested that a polyketide synthase (PKS) catalyzes the synthesis of the first precursor of the cannabinoid pathway, the olivetolic acid. However, the identification of flavonoids and stilbenoids in the plant involve the presence of more than one PKS.
