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Observational Study Agreement • November 9th, 2016

OBSERVATIONAL STUDY AGREEMENT SMLOUVů O PROVÁDENÍ OBSERVůČNÍSTUDIE This Observational Study Agreement (the “Agreement”), is made as of the Effective Date (as defined below), by and between Biogen Idec Research Limited with a place of business at Innovation House, 70, Norden Road, Maidenhead, Berkshire, SL6 4AY, United Kingdom (“Biogen”), Fakultní nemocnice Hradec Králové, having a place of business at Sokolská 581, post code 500 05 Hradec Králové– Nový Hradec Králové, Czech Republic, Identification number: 00179906, Tax identification number: CZ00179906, represented by prof. MUDr. Vladimír Palička, CSc., dr. h. c., Director (the “Provider”),address Neurology Clinic of Fakultní nemocnice Hradec Králové, Sokolská 581, 500 05 Hradec Králové, Czech Republic (the “Investigator”) and Quintiles Czech Republic, s.r.o., Praha 5, Jinonice, Radlická 714/113a, 158 00, Czech Republic, Identification Number: 24768 651, Tax identification Number: CZ247 68 651acting on the basis of Power of Attorney d

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