Common Contracts
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PROJECT 1 ABSTRACTArs Agreement • April 1st, 2020
Project Goals: The long-term goal of the PI’s research is to develop strategies for controlling FHB and mycotoxin accumulation that complement existing control measures in wheat and barley. While breeding efforts target host genes to enhance resistance, host-induced gene silencing (HIGS) provides an in planta strategy to silence expression of fungal genes to control infection and toxin accumulation. The goal of the proposed work is to test the hypothesis that HIGS of Fusarium graminearum effector genes, which are required for virulence, will adversely impact pathogenicity and thus promote FHB resistance in wheat. The efficacy of this approach to promote resistance against F. graminearum has been validated in Arabidopsis thaliana. Two fungal virulence factor-encoding genes will be targeted for HIGS in wheat: (i) FGL1, which encodes a lipase that is required for spread of the infection, and (ii) FgNahG, which encodes a hydroxylase that metabolizes the plant defense signaling metabolite s
