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Contract On • June 13th, 2022

AMEDMENT NO. 1 TO CONTRACT ON CLINICAL TRIAL This Amendment to Contract on Clinical Trial (“Amendment”) is made by and between: F. Hoffmann-La Roche Ltd, having a place of business at Grenzacherstrasse 124, 4070 Basel, Switzerland, represented by Quintiles Czech Republic s.r.o., (Hereinafter referred to as the ‘Sponsor’), and Contractual research organization Quintiles Czech Republic, s.r.o., having a place of business at Praha 5, Jinonice, Radlická 714/113a, zip code 158 00, Czech Republic, Identification number: 247 68 651, Tax Identification number: CZ247 68 651, (Hereinafter referred to as the ‘Contractual research organization’), and Fakultní nemocnice v Motole, located at V Úvalu 84, 150 06 Praha 5, Czech Republic, Company ID no.: 00064203, Tax ID no:CZ00064203, r the ‘MedicalFacility’) and is valid as of the last signature date below („Validity date“) and is effective as of the date of publication in the Agreement Register. („Effective date“). WITNESSETH: WHEREAS, Contractual re

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