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Clinical Trial Agreement • October 29th, 2018

CLINICAL TRIAL AGREEMENT No. 08/OVZ/18/017-P This CLINICAL TRIAL AGREEMENT (the“Agreement”) is effective on the day of the publishing in accordance with the Act no. 340/2015 Coll. On the Register of Contracts (the “Effective Date”), by and between Fakultní nemocnice Ostrava located at 17. listopadu 1790, 708 52 Ostrava, Czech Republic, Organization ID No.: 00843989, VAT Reg. No.: CZ00843989, person authorized to act and sign in respect of this Agreement: MUDr. Josef Srovnal, Deputy Director for Medical Care, Bank details: Česká národní banka, Na Příkopě 28, 115 03 Prague 1, Account No.: 66332761/0710, IBAN: CZ59 0710 0000 0000 6633 2761, SWIFT:CNBACZPP, variable symbol for this study: 649071148 (the “Institution”), Pharmaceutical Research Associates CZ, s.r.o., located at Praha 7, Jankovcova 1569/2c, Post Code (PSČ): 170 00, Czech Republic, IČ (company ID number): 27636852, the limited liability company duly registered in the Commercial Register of the Czech Republic maintained by the

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