AG348-C-006October 16th, 2019
FiledOctober 16th, 2019English Czech CLINICAL TRIAL AGREEMENT SMLOUVA O KLINICKÉM HODNOCENÍ THIS CLINICAL TRIAL AGREEMENT (together with Exhibit A, the “Agreement”) is by and among AGIOS PHARMACEUTICALS, INC., a United StatesDelaware corporation with an office at 88 Sidney Street, Cambridge, MA 02139 (“Sponsor” or “Agios”) and COVANCE INC., having registered office at 210 Carnegie Center, Princeton, New Jersey, 08450-6233, USA, (“CRO”) and ÚSTAV HEMATOLOGIE A KREVNÍ TRANSFUZE,having registered office at U Nemocnice 2094/1, Praha 2, 128 20, Czech Republic, ID 00023736, represented by Prof. Petr Cetkovský, MD, PhD, MBA, director (“Institution”) and , with business address U Nemocnice 2094/1, Praha 2, 128 20, Czech Republic (“Investigator”) when signed by all parties, is effective as of the date of last signature (the “Validity Date”). To the extent mandated by applicable law, the Agreement becomes effective not earlier than the date of publication in the Czech Republic contract register (the “Effective