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Contract

Trial Agreement • December 15th, 2023

• Contract Type
  Trial Agreement
• Filed
  December 15th, 2023

CLINICAL TRIAL AGREEMENT This CLINICAL TRIAL AGREEMENT (the“Agreement”) is effective on the date of by publishing in accordance with the Act no. 340/2015 Coll. On the Register of Contract (the “Effective Date”), by and between Institut klinické a experimentální medicíny located at Vídeňská 1958/9, 140 21 Praha 4, Czech Republic, IČO (Company ID): 00023001, VAT: CZ 00023001, represented by Ing. Helena Rögnerová, director (the “Institution”), ICON Clinical Research Czech Republic s.r.o., located at V parku 2335/20, Chodov, Prague 4, PSČ 148 007, Czech Republic, IČO (company ID number): 27636852, the limited liability company duly registered in the Commercial Register of the Czech Republic maintained by the Municipal Court in Prague, Section C, Entry 120574, represented by xxxxxxxx. authorized representative based on power of attorney (“PRA”), acting as an independent contractor for Ionis Pharmaceuticals, Inc. se sídlem 2855 Gazelle Court, Carlsbad, CA 92010, USA (the “Sponsor”), legally