ContractClinical Trial Agreement • October 19th, 2021
Contract Type FiledOctober 19th, 2021AMENDMENT No.4 TO CLINICAL TRIAL AGREEMENT DODATEK Č.4 SMLOUVY O KLINICKÉM HODNOCENÍ This Amendment No.4 (this “Amendment”) to the Clinical Trial Agreement (the “Agreement”), dated 24 March 2017 as amended by Amendment No,1 dated 21 May 2019 and Amendment No.2 dated 26 March2020 and Amendment No. 3 dated 2 December 2020, by and between: • Fakultní nemocnice v Motole, state budgetary organization having a place of business at V Úvalu 84/1, 150 06, Prague 5, Czech Republic, Identification number: 00064203, Tax identification number: CZ00064203, represented byby delegation (the “Institution”),and • IQVIA RDS Czech Republic, s.r.o., having a place of business at Pernerova 691/42, 186 00 Praha 8, Czech Republic (“IQVIA”), and • Merck KGaA, having a place of business at Frankfurter Str. 250, Darmstadt, Germany upon Power of Attorney represented by IQVIA RDS Czech Republic, s.r.o. (“Sponsor”) is entered into as of the last signature date below and effective as of its publication in the Regist