0000318771-06-000025 Sample Contracts

LETTER AMENDMENT TO AGREEMENT
Collaboration Agreement • August 3rd, 2006 • Genentech Inc • Pharmaceutical preparations • California

This Letter Amendment to the Agreement (as defined below) (the “Letter Amendment”) effective as of August 21, 2003 (the “Letter Amendment Effective Date”), is entered into by and between IDEC PHARMACEUTICALS CORPORATION, a Delaware corporation having its principal place of business at 3030 Callan Road, San Diego, California 92121 ("IDEC") and GENENTECH, INC., a Delaware corporation having its principal place of business at 1 DNA Way, South San Francisco, California 94080 ("Genentech"), each on behalf of itself and its Affiliates.

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AMENDED AND RESTATED COLLABORATION AGREEMENT GENENTECH, INC. AND IDEC PHARMACEUTICALS CORPORATION
Collaboration Agreement • August 3rd, 2006 • Genentech Inc • Pharmaceutical preparations • California

THIS AMENDED AND RESTATED COLLABORATION AGREEMENT (this “Agreement) is made effective as of the 19th day of June, 2003 (the "Restated Effective Date") by and between IDEC Pharmaceuticals Corporation, a Delaware corporation having its principal place of business at 3030 Callan Road, San Diego, California 92121 ("IDEC") and GENENTECH, INC., a Delaware corporation having its principal place of business at 1 DNA Way, South San Francisco, California 94080 ("Genentech"), each on behalf of itself and its Affiliates. IDEC and Genentech are sometimes referred to herein individually as a "Party" and collectively as the "Parties," and references to "IDEC" and "Genentech" shall include their respective Affiliates.

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