EXHIBIT 1 SECOND AMENDMENT TO RIGHTS AGREEMENT THIS SECOND AMENDMENT (the "Amendment") is entered into as of December 13, 1999 by ADVANCED TISSUE SCIENCES, INC., a Delaware corporation (the "Company"), and CHASEMELLON SHAREHOLDER SERVICES, L.L.C., a...Rights Agreement • March 28th, 2000 • Advanced Tissue Sciences Inc • Biological products, (no disgnostic substances) • Delaware
