Exhibit 1 FIRST AMENDMENT TO RIGHTS AGREEMENT THIS AMENDMENT (the "Amendment") is entered into as of November 8, 1999, by and between ADVANCED TISSUE SCIENCES, INC., a Delaware corporation (the "Company"), and CHASEMELLON SHAREHOLDERS SERVICES,...Rights Agreement • November 12th, 1999 • Advanced Tissue Sciences Inc • Biological products, (no disgnostic substances) • Delaware
Exhibit 2 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this "Agreement"), dated as of November 5, 1999, is entered into by and between each of the parties who are designated as Purchasers on the signature page to this Agreement...Securities Purchase Agreement • November 12th, 1999 • Advanced Tissue Sciences Inc • Biological products, (no disgnostic substances) • California
