0000872947-10-000006 Sample Contracts

FIFTH AMENDMENT AGREEMENT<?xml:namespace prefix = o ns = "urn:schemas- microsoft-com:office:office" />
Fifth Amendment Agreement • March 24th, 2010 • Applied Neurosolutions Inc • Biological products, (no disgnostic substances)

This Fifth Amendment Agreement is made effective November ___, 2009 by and between Albert Einstein College of Medicine of Yeshiva University, a Division of Yeshiva University, a corporation organized and existing under the laws of the State of New York, having an office and place of business at 1300 Morris Park Avenue, Bronx, New York 10461 ("AECOM") and Applied NeuroSolutions, Inc. (formerly known as Molecular Geriatrics Corp.), a corporation organized and existing under the laws of the State of Delaware, having an office and place of business at 50 Lakeview Parkway, Suite 111, Vernon Hills, Illinois 60061 ("Licensee").

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CONFIDENTIAL PORTIONS OF THIS AGREEMENT HAVE BEEN OMITTED AND FILED SEPARATELY WITH THE COMMISSION PURSUANT TO A REQUEST FOR CONFIDENTIAL TREATMENT.<?xml:namespace prefix = o ns = "urn:schemas-microsoft- com:office:office" />
Second Amendment • March 24th, 2010 • Applied Neurosolutions Inc • Biological products, (no disgnostic substances)

This Second Amendment (the "Second Amendment") to the Collaboration Agreement dated as of November 27, 2006, and as amended as of November 25, 2009 (the "Agreement"), is effective as of December 20, 2009 ("Second Amendment Effective Date"), between Eli Lilly and Company, a corporation organized and existing under the laws of the State of Indiana ("LILLY"), and Applied NeuroSolutions, Inc., a corporation organized and existing under the laws of the State of Delaware ("APNS").

CONFIDENTIAL PORTIONS OF THIS AGREEMENT HAVE BEEN OMITTED AND FILED SEPARATELY WITH THE COMMISSION PURSUANT TO A REQUEST FOR CONFIDENTIAL TREATMENT. AMENDMENT
Collaboration Agreement • March 24th, 2010 • Applied Neurosolutions Inc • Biological products, (no disgnostic substances)

This Amendment (the "Amendment") to the Collaboration Agreement dated as of November 27, 2006 (the "Agreement"), is effective as of November 25, 2009 (" Amendment Effective Date"), between Eli Lilly and Company, a corporation organized and existing under the laws of the State of Indiana ("Lilly"), and Applied NeuroSolutions, Inc., a corporation organized and existing under the laws of the State of Delaware ("APNS").

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