0000874015-14-000095 Sample Contracts

Amended and Restated Collaboration and License Agreement
Collaboration and License Agreement • November 7th, 2014 • Isis Pharmaceuticals Inc • Pharmaceutical preparations • New York

This Amended and Restated Collaboration and License Agreement (“Agreement”) is made effective October 26, 2011 (the “Restatement Date”) and is entered into by and between Cold Spring Harbor Laboratory, a research and education institution having an address at One Bungtown Road, Cold Spring Harbor, New York 11724 (“CSHL”) and Isis Pharmaceuticals, Inc., a Delaware corporation having an address at 2855 Gazelle Court, Carlsbad, California 92010 (“Isis”).

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EXCLUSIVE LICENSE AGREEMENT
Exclusive License Agreement • November 7th, 2014 • Isis Pharmaceuticals Inc • Pharmaceutical preparations • Massachusetts

This Exclusive License Agreement (the “Agreement”), effective as of January 14, 2010 (the “Effective Date”), is between the University of Massachusetts (“University”), a public institution of higher education of the Commonwealth of Massachusetts as represented by its Worcester campus, and Isis Pharmaceuticals, Inc. (“Isis”), a Delaware corporation.

Amendment to Amended and Restated Collaboration and License Agreement relating to [***]
Collaboration and License Agreement • November 7th, 2014 • Isis Pharmaceuticals Inc • Pharmaceutical preparations

This Agreement (“Agreement”) is made effective March 14, 2014 and is entered into by and between Cold Spring Harbor Laboratory, a research and education institution having an address at One Bungtown Road, Cold Spring Harbor, New York 11724 (“CSHL”) and Isis Pharmaceuticals, Inc., a Delaware corporation having an address at 2855 Gazelle Court, Carlsbad, California 92010 (“Isis”).

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