Strategic Collaboration Agreement Between Isis Pharmaceuticals, Inc., And AstraZeneca ABStrategic Collaboration Agreement • November 9th, 2015 • Isis Pharmaceuticals Inc • Pharmaceutical preparations • New York
This STRATEGIC COLLABORATION AGREEMENT (the “Agreement”) is entered into as of the 31st day of July, 2015 (the “Execution Date”) by and between Isis Pharmaceuticals, Inc., a Delaware corporation, having its principal place of business at 2855 Gazelle Court, Carlsbad, CA 92010 (“Isis”), and AstraZeneca AB, a company incorporated in Sweden under no. 556011-7482 with its registered office at SE-151 85 Södertälje, Sweden (“AstraZeneca”). AstraZeneca and Isis each may be referred to herein individually as a “Party” or collectively as the “Parties.” Capitalized terms used in this Agreement, whether used in the singular or the plural, have the meaning set forth in Appendix 1. All attached appendices, exhibits and schedules are a part of this Agreement.
Attachment I Isis Pharmaceuticals, Inc. Option Agreement (Nonstatutory Stock Option) For Options Granted After September 30, 2015Option Agreement • November 9th, 2015 • Isis Pharmaceuticals Inc • Pharmaceutical preparations
Pursuant to your Stock Option Grant Notice (“Grant Notice”) and this Option Agreement, Isis Pharmaceuticals, Inc. (the “Company”) has granted you an option under its 2011 Equity Incentive Plan (the “Plan”) to purchase the number of shares of the Company’s Common Stock indicated in your Grant Notice at the exercise price indicated in your Grant Notice. Capitalized terms not explicitly defined in this Option Agreement but defined in the Plan shall have the same definitions as in the Plan.
AMENDMENT #6 TO RESEARCH, DEVELOPMENT AND LICENSE AGREEMENTResearch, Development and License Agreement • November 9th, 2015 • Isis Pharmaceuticals Inc • Pharmaceutical preparations
This AMENDMENT #6 TO THE RESEARCH, DEVELOPMENT AND LICENSE AGREEMENT (this “Amendment No. 6”) is entered into and made effective as of the 2nd day of September, 2015 (the “Amendment No. 6 Date”) by and between Isis Pharmaceuticals, Inc., a Delaware corporation, having its principal place of business at 2855 Gazelle Court, Carlsbad, CA 92010 (“Isis”), and Glaxo Group Limited, a company existing under the laws of England and Wales, having its registered office at 980 Great West Road, Brentford, London TW8 9GS, United Kingdom (“GGL”), and Glaxosmithkline intellectual property development limited, a company existing under the laws of England and Wales, having its registered office at 980 Great West Road, Brentford London TW8 9GS, United Kingdom (“GSK IPDL”). GGL and GSK IPDL are referred to together as (“GSK”). Isis and GSK are each referred to herein by name or as a “Party” or, collectively, as “Parties.”
Isis Pharmaceuticals, Inc. Supplemental Stock Option AgreementSupplemental Stock Option Agreement • November 9th, 2015 • Isis Pharmaceuticals Inc • Pharmaceutical preparations
Isis Pharmaceuticals, Inc. (the "Company"), pursuant to its 1989 Stock Option Plan (the "Plan") has this day granted to the undersigned optionee, an option to purchase shares of the common stock of the Company ("Common Stock") as described herein. This option is not intended to qualify and will not be treated as an "incentive stock option" within the meaning of Section 422 of the Internal Revenue Code of 1986, as amended from time to time (the "Code"). This option is subject to all of the terms and conditions as set forth herein and on Attachment I hereto, which is incorporated herein in its entirety.
AMENDMENT NUMBER ONE TO THE SECOND AMENDED AND RESTATED STRATEGIC COLLABORATION AND LICENSE AGREEMENTStrategic Collaboration and License Agreement • November 9th, 2015 • Isis Pharmaceuticals Inc • Pharmaceutical preparations
THIS AMENDMENT NUMBER ONE (the “Amendment”) to the Second Amended and Restated Strategic Collaboration and License Agreement is entered into as of the 13 day of July, 2015 (the “Amendment Effective Date”) by and among Alnylam Pharmaceuticals, Inc., a Delaware corporation, with its principal place of business at 300 Third Street, Cambridge, Massachusetts 02142 (“Alnylam”), and Isis Pharmaceuticals, Inc., a Delaware corporation, with its principal place of business at 2855 Gazelle Court, Carlsbad, California 92010 (“Isis”).
