0000874015-21-000166 Sample Contracts

COLLABORATION AND LICENSE AGREEMENT between BICYCLETX LIMITED and IONIS PHARMACEUTICALS, INC. Dated as of July 9, 2021

Collaboration and License Agreement • November 3rd, 2021 • Ionis Pharmaceuticals Inc • Pharmaceutical preparations • New York

• Contract Type
  Collaboration and License Agreement
• Filed
  November 3rd, 2021
• Company
  Ionis Pharmaceuticals Inc
• Industry
  Pharmaceutical preparations
• Jurisdiction
  New York

This Collaboration and License Agreement (the “Agreement”) is made and entered into effective as of July 9, 2021 (the “Effective Date”) by and between BicycleTx Limited, a company incorporated in England and Wales with a place of business at Building 900, Babraham Research Campus, Cambridge CB22 3AT, UK (“BicycleTx”), and Ionis Pharmaceuticals, Inc., a Delaware corporation with a principal place of business at 2855 Gazelle Court, Carlsbad, California 92010, USA (“Ionis”). BicycleTx and Ionis are referred to herein individually as a “Party” and collectively as the “Parties”.

Amended and Restated Neurology Drug Discovery and Development Collaboration, Option and License Agreement Between Ionis Pharmaceuticals, Inc., And Biogen MA Inc.

Neurology Drug Discovery and Development Collaboration, Option and License Agreement • November 3rd, 2021 • Ionis Pharmaceuticals Inc • Pharmaceutical preparations • Delaware

• Contract Type
  Neurology Drug Discovery and Development Collaboration, Option and License Agreement
• Filed
  November 3rd, 2021
• Company
  Ionis Pharmaceuticals Inc
• Industry
  Pharmaceutical preparations
• Jurisdiction
  Delaware

This AMENDED AND RESTATED NEUROLOGY DRUG DISCOVERY AND DEVELOPMENT COLLABORATION, OPTION AND LICENSE AGREEMENT (the “Agreement”) is entered into as of the 12th day of July, 2021 (the “Amendment Date”) by and between Ionis Pharmaceuticals, Inc. (formerly known as Isis Pharmaceuticals, Inc.), a Delaware corporation, having its principal place of business at 2855 Gazelle Court, Carlsbad, CA 92010 (“Ionis”), and Biogen MA Inc. (formerly known as Biogen Idec MA Inc.), a Massachusetts corporation, having its principal place of business at 225 Binney Street, Cambridge, MA 02142 (“Biogen”). Biogen and Ionis each may be referred to herein individually as a “Party” or collectively as the “Parties.” Capitalized terms used in this Agreement, whether used in the singular or the plural, have the meaning set forth in Appendix 1. All attached appendices and schedules are a part of this Agreement.