0000874015-23-000186 Sample Contracts

AMENDMENT NO. 3 TO COLLABORATION AND LICENSE AGREEMENT
Collaboration and License Agreement • August 9th, 2023 • Ionis Pharmaceuticals Inc • Pharmaceutical preparations

This Amendment No. 3 to Collaboration and License Agreement (“Third Amendment”) is made and entered into effective as of 27th April 2023 (“Third Amendment Effective Date”) by and between BicycleTx Limited, a company incorporated in England and Wales with a place of business at Blocks A & B, Portway Building Granta Park, Great Abington, Cambridge, United Kingdom, CB21 6GS (“BicycleTx”), and Ionis Pharmaceuticals, Inc., a Delaware corporation with a principal place of business at 2855 Gazelle Court, Carlsbad, California 92010, USA (“Ionis”).

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FIRST AMENDMENT TO PURCHASE AND SALE AGREEMENT
Purchase and Sale Agreement • August 9th, 2023 • Ionis Pharmaceuticals Inc • Pharmaceutical preparations • California

THIS FIRST AMENDMENT TO PURCHASE AND SALE AGREEMENT (this “Amendment”) is entered into as of June 15, 2023, by and between IONIS PHARMACEUTICALS, INC., a Delaware corporation (“Seller”) and OXFORD I ASSET MANAGEMENT USA INC., a Delaware corporation (“Buyer”).

Contract
Letter Agreement • August 9th, 2023 • Ionis Pharmaceuticals Inc • Pharmaceutical preparations

Certain portions of this exhibit, marked by [***], have been excluded because they are both not material and are the type that the registrant treats as private or confidential.

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