0000891020-07-000098 Sample Contracts

AMENDED AND RESTATED NORTHWEST BIOTHERAPEUTICS, INC. LOAN AGREEMENT and 10% PROMISSORY NOTE
Loan Agreement • April 17th, 2007 • Northwest Biotherapeutics Inc • Pharmaceutical preparations • Delaware
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NORTHWEST BIOTHERAPEUTICS, INC. WARRANT
Warrant Agreement • April 17th, 2007 • Northwest Biotherapeutics Inc • Pharmaceutical preparations • Delaware

This Certifies That, for value received, Toucan Partners, LLC, with its principal office at 7600 Wisconsin Avenue, Suite 700, Bethesda, MD 20814, and/or its assigns (collectively, the “Holder”), is entitled to subscribe for and purchase from Northwest Biotherapeutics, Inc., a Delaware corporation, with its principal office at 17801 120th Avenue NE, Suite 101, Bothell, Washington 98011 (the “Company”), such number of Exercise Shares as provided herein at the Exercise Price (each subject to adjustment as provided herein). This Warrant is being issued pursuant to the terms of the Amended and Restated Recapitalization Agreement, dated July 30, 2004, as amended on October 22, 2004, November 10, 2004, December 27, 2004, January 26, 2005, April 12, 2005, May 13, 2005, June 16, 2005, July 26, 2005, September 7, 2005 and November 14, 2005, by and among the Company and Toucan Capital Fund II, L.P. (the “Recapitalization Agreement”).

NORTHWEST BIOTHERAPEUTICS, INC. WARRANT
Warrant Agreement • April 17th, 2007 • Northwest Biotherapeutics Inc • Pharmaceutical preparations • Delaware

This Certifies That, for value received and subject to the provisions set forth in this amended and restated warrant (this “Warrant”), Toucan Partners, LLC, with its principal office at 7600 Wisconsin Avenue, Suite 700, Bethesda, MD 20814, and/or its assigns (collectively, the “Holder”), is entitled to subscribe for and purchase from Northwest Biotherapeutics, Inc., a Delaware corporation, with its principal office at 17801 120th Avenue NE, Suite 101, Bothell, Washington 98011 (the “Company”), such number of Exercise Shares as provided herein at the Exercise Price (each subject to adjustment as provided herein). This Warrant is amended and restated in its entirety as of April ___, 2007 (the “Restatement Date”), and amends, restates and supersedes in full that certain Warrant No. BW-___dated as of ___,, 200___issued by the Company in favor of the Holder (the “Original Warrant”) issued pursuant to the terms of the Amended and Restated Recapitalization Agreement, dated July 30, 2004, as a

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