0000891618-03-001536 Sample Contracts

AMENDMENT TO AMENDED AND RESTATED LINE OF CREDIT AGREEMENT
Line of Credit Agreement • March 31st, 2003 • Nuvelo Inc • In vitro & in vivo diagnostic substances • California

THIS AMENDMENT TO AMENDED AND RESTATED LINE OF CREDIT AGREEMENT, dated as of November 9, 2002 (this “Amendment”), is entered into by Hyseq, Inc., a Nevada corporation (the “Company”), and Dr. George B. Rathmann (“Dr. Rathmann”).

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GUARANTY
Guaranty • March 31st, 2003 • Nuvelo Inc • In vitro & in vivo diagnostic substances • California

THIS GUARANTY (“Guaranty”) is made as of October 1, 2002 by George Rathmann, an individual (“Guarantor”), in favor of AMB PROPERTY, L.P., a Delaware limited partnership (“Seller”).

CONDITIONAL LEASE TERMINATION AGREEMENT
Conditional Lease Termination Agreement • March 31st, 2003 • Nuvelo Inc • In vitro & in vivo diagnostic substances • California

THIS CONDITIONAL LEASE TERMINATION AGREEMENT (this “Termination Agreement”) is made as of the 1st day of October, 2002 by and among AMB PROPERTY, L.P., a Delaware limited partnership (“Landlord”), HYSEQ, INC., a Nevada corporation (“Tenant”), and GEORGE RATHMANN, an individual (“Guarantor”).

REAL PROPERTY OPTION AND SALE AGREEMENT AND JOINT ESCROW INSTRUCTIONS
Real Property Option and Sale Agreement and Joint Escrow Instructions • March 31st, 2003 • Nuvelo Inc • In vitro & in vivo diagnostic substances • California

THIS REAL PROPERTY OPTION AND SALE AGREEMENT AND JOINT ESCROW INSTRUCTIONS (this “Agreement”) is made as of October 1, 2002 by and between AMB PROPERTY, L.P., a Delaware limited partnership (“Seller”), and HYSEQ, INC., a Nevada corporation (“Buyer”).

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