0000891618-05-000437 Sample Contracts

CONNETICS CORPORATION CHANGE OF CONTROL AGREEMENT
Change of Control Agreement • June 20th, 2005 • Connetics Corp • Pharmaceutical preparations • California

This Change of Control Agreement (the “Agreement”) is made and entered into effective as of January 1, 2002 (the “Effective Date”), by and between Thomas G. Wiggans (the “Employee”) and Connetics Corporation, a Delaware corporation (“Connetics”). Certain capitalized terms used in this Agreement are defined in Section 1 below.

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CONNETICS CORPORATION CONSULTANT CHANGE OF CONTROL AGREEMENT
Consultant Change of Control Agreement • June 20th, 2005 • Connetics Corp • Pharmaceutical preparations • California

This Consultant Change of Control Agreement (the “Agreement”) is made and entered into effective as of January 1, 2002 (the “Effective Date”), by and between G. Kirk Raab (the “Consultant”) and Connetics Corporation, a Delaware corporation (“Connetics”). Certain capitalized terms used in this Agreement are defined in Section 1 below.

CONNETICS CORPORATION NON-QUALIFIED STOCK OPTION AGREEMENT
Non-Qualified Stock Option Agreement • June 20th, 2005 • Connetics Corp • Pharmaceutical preparations • California

Connetics Corporation, a Delaware corporation (the “Corporation”), effective May 16, 2005, hereby grants to Michael Eison (the “Optionee”), an option to purchase a maximum of 30,000 shares (the “Option Shares”) of its Common Stock, at an exercise price equal to the fair market value on the date of grant with the following terms and conditions:

CONNETICS CORPORATION OUTSIDE DIRECTOR CHANGE OF CONTROL AGREEMENT
Outside Director Change of Control Agreement • June 20th, 2005 • Connetics Corp • Pharmaceutical preparations • California

This Change of Control Agreement (the “Agreement”) is made and entered into effective as of ___, 2001 (the “Effective Date”), by and between ___(the “Director”) and Connetics Corporation, a Delaware corporation (“Connetics”). Certain capitalized terms used in this Agreement are defined in Section 1 below.

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