Exhibit 2.1 SECOND AMENDMENT AGREEMENT This SECOND AMENDMENT AGREEMENT (this "Second Amendment Agreement") is made and entered into as of 30 October 1997 by and between F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, CH-4070 Basel, Switzerland...Second Amendment Agreement • December 18th, 1997 • Icn Pharmaceuticals Inc • Pharmaceutical preparations
