0000899140-16-000957 Sample Contracts

Apricus Biosciences, Inc. 11975 El Camino Real, Suite 300 San Diego, California 92130
Subscription Agreement • January 14th, 2016 • Sarissa Capital Management LP • Pharmaceutical preparations • New York

The undersigned (collectively, the “Investors”) hereby severally confirm their respective agreements with Apricus Biosciences, Inc., a Nevada corporation (the “Company”), as follows:

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AMENDMENT TO WARRANTS
Warrant Amendment • January 14th, 2016 • Sarissa Capital Management LP • Pharmaceutical preparations • New York

THIS AMENDMENT TO WARRANTS (this “Amendment”), dated as of January 12, 2016, is by and between Apricus Biosciences, Inc., a Nevada corporation (the “Company”), and the holders named on the signature pages hereto (the “Holders”).

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