0000899140-18-000409 Sample Contracts

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Purchase Common Stock • June 22nd, 2018 • Sarissa Capital Management LP • Pharmaceutical preparations • New York
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AMENDMENT NO. 1 TO SUBSCRIPTION AGREEMENT
Subscription Agreement • June 22nd, 2018 • Sarissa Capital Management LP • Pharmaceutical preparations • New York

This AMENDMENT NO. 1 TO SUBSCRIPTION AGREEMENT (this “Amendment”) is dated as of June 22, 2018, by and among Sarissa Capital Domestic Fund LP, a Delaware limited partnership (“Sarissa Domestic”), Sarissa Capital Offshore Master Fund LP, a Delaware limited partnership (together with Sarissa Domestic, the “Investors”) and Apricus Biosciences, Inc., a Nevada corporation (the “Company”). The Investors and the Company are each referred to herein by name or, individually, as a “Party” or collectively, as “Parties.”

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