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Securities Purchase Agreement • January 16th, 2002 • Ribozyme Pharmaceuticals Inc • Pharmaceutical preparations • New York

SECURITIES PURCHASE AGREEMENT, dated as of December 21, 2001 (this "Agreement"), by and between Ribozyme Pharmaceuticals, Inc., a Delaware corporation (the "Company"), and Elan International Services, Ltd., a Bermuda exempted limited liability company (the "Purchaser").

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