Exhibit 4.2 AGREEMENT IN PRINCIPLE THIS AGREEMENT IN PRINCIPLE, dated as of January 6, 1998 (this "Agreement"), by and between NAPRO BIOTHERAPEUTICS, INC., a Delaware corporation (the "Company"), and the undersigned holder (the "Holder") of one of the...Agreement in Principle • January 12th, 1998 • Napro Biotherapeutics Inc • Medicinal chemicals & botanical products • New York
