EXHIBIT 4.1 AMENDMENT NO. 3 TO SHAREHOLDER PROTECTION RIGHTS AGREEMENT THIS AMENDMENT NO. 3, dated as of May 15, 2002 (the "Amendment"), to the Shareholder Protection Rights Agreement, dated as of September 15, 1997, as amended by Amendment No. 1...Shareholder Protection Rights Agreement • May 20th, 2002 • Collagenex Pharmaceuticals Inc • Pharmaceutical preparations • Delaware
