Exhibit 2.1(c) SECOND AMENDMENT TO AGREEMENT AND PLAN OF MERGER THIS SECOND AMENDMENT TO AGREEMENT AND PLAN OF MERGER (the "Amendment") is dated as of December 30, 2005, by and among Cougar Biotechnology, Inc., a Delaware corporation ("Cougar"), GVC...Agreement and Plan of Merger • January 5th, 2006 • GVC Venture Corp • Non-operating establishments
