EXHIBIT 10.4 Optionee: STANLEY T. CROOKE Date: JANUARY 6, 2000 ----------------------------- ----------------------- ISIS PHARMACEUTICALS, INC. SUPPLEMENTAL STOCK OPTION AGREEMENT Isis Pharmaceuticals, Inc. (the "Company"), pursuant to its 1989 Stock...Supplemental Stock Option Agreement • February 28th, 2001 • Isis Pharmaceuticals Inc • Pharmaceutical preparations
