EXECUTION COPY AMENDMENT NO. 1 TO THE AMENDED AND RESTATED INVESTORS' AGREEMENT AMENDMENT NO. 1 dated as of June 15, 2001 to the Amended and Restated Investors' Agreement dated as of June 19, 2000, as amended (the "INVESTORS' AGREEMENT"). W I T N E S...Investors' Agreement • August 10th, 2001 • Charles River Laboratories Inc • Biological products, (no disgnostic substances) • Delaware
