0000912057-01-542387 Sample Contracts

EXHIBIT 10.1 MASTER LOAN AND SECURITY AGREEMENT NO. 83834
Master Loan and Security Agreement • December 7th, 2001 • Triangle Pharmaceuticals Inc • Pharmaceutical preparations

This Agreement includes the attached Rider (containing amendments labeled 1-23) which are incorporated into the Agreement. /s/ RA /s/ --------------- ------------ RIDER TO MASTER LOAN AND SECURITY AGREEMENT NO. 83834 -------------------------------------------------------------------------------- Wells Fargo Equipment Finance, Inc. ("Secured Party") and Triangle Pharmaceuticals, Inc. ("Debtor") hereby agree to amend the Agreement as follows: 1. In the eighth line of Section 3 of the Agreement, delete the words "howsoever arising or evidenced including without limitation those" and insert instead "under the Agreement evidenced by or". 2. In the seventh line of Section 6 of the Agreement, after the words "Debtor shall, at the option of", insert the words "Debtor, unless an Event of Default has occurred, otherwise at the option of", and in the eleventh line of Section 6, after the words "damaged and, in the", insert the words "discretion of Debtor, unless an Event of Default has occurred,

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