0000912057-02-012415 Sample Contracts

SECOND AMENDMENT TO COLLABORATION AGREEMENT
Collaboration Agreement • March 29th, 2002 • Rigel Pharmaceuticals Inc • Pharmaceutical preparations

THIS SECOND AMENDMENT TO COLLABORATION AGREEMENT (the "Second Amendment") is entered into and made effective as of December 4, 2001 ("Second Amendment Date") by and between RIGEL PHARMACEUTICALS, INC., a Delaware corporation ("Rigel") with its offices at 240 East Grand Avenue, South San Francisco, California, 94080, and JANSSEN PHARMACEUTICA N.V., a Belgian corporation ("Janssen") with offices at Turnhoutseweg 30, 2340 Beerse, Belgium (Rigel and Janssen each individually referred to herein as "Party", and collectively as "Parties").

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