0000912057-15-000049 Sample Contracts

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Contract
Warrant Agreement • March 3rd, 2015 • Collegium Pharmaceutical Inc • Pharmaceutical preparations • California

THIS WARRANT AND THE SHARES ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR THE SECURITIES LAWS OF ANY STATE AND, EXCEPT AS SET FORTH IN SECTIONS 5.3 AND 5.4 BELOW, MAY NOT BE OFFERED, SOLD, PLEDGED OR OTHERWISE TRANSFERRED UNLESS AND UNTIL REGISTERED UNDER SAID ACT AND LAWS OR, IN THE OPINION OF LEGAL COUNSEL IN FORM AND SUBSTANCE SATISFACTORY TO THE ISSUER, SUCH OFFER, SALE, PLEDGE OR OTHER TRANSFER IS EXEMPT FROM SUCH REGISTRATION.

Contract
Warrant Agreement • March 3rd, 2015 • Collegium Pharmaceutical Inc • Pharmaceutical preparations • California

THIS WARRANT AND THE SHARES ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR THE SECURITIES LAWS OF ANY STATE AND, EXCEPT AS SET FORTH IN SECTIONS 5.3 AND 5.4 BELOW, MAY NOT BE OFFERED, SOLD, PLEDGED OR OTHERWISE TRANSFERRED UNLESS AND UNTIL REGISTERED UNDER SAID ACT AND LAWS OR, IN THE OPINION OF LEGAL COUNSEL IN FORM AND SUBSTANCE SATISFACTORY TO THE ISSUER, SUCH OFFER, SALE, PLEDGE OR OTHER TRANSFER IS EXEMPT FROM SUCH REGISTRATION.

COLLEGIUM PHARMACEUTICAL, INC. Restricted Stock Award Agreement Under 2012 Stock Incentive Plan
Restricted Stock Award Agreement • March 3rd, 2015 • Collegium Pharmaceutical Inc • Pharmaceutical preparations • Delaware

THIS RESTRICTED STOCK AWARD AGREEMENT (this “Agreement”) is made as of March 5, 2014 (the “Grant Date”) by and between Collegium Pharmaceutical, Inc., a Delaware corporation (the “Company”), and Gino Santini (the “Participant”).

SUBORDINATION AGREEMENT
Subordination Agreement • March 3rd, 2015 • Collegium Pharmaceutical Inc • Pharmaceutical preparations • California

This Subordination Agreement (the “Agreement”) is made as of December 2, 2014, by and between each of the undersigned creditors named on the signature pages hereto (each a “Creditor” and, collectively, the “Creditors”), COLLEGIUM PHARMACEUTICAL, INC., a Virginia corporation (“Borrower”), and SILICON VALLEY BANK, a California corporation, with its principal place of business at *** (“Bank”).

Contract
Subordination Agreement • March 3rd, 2015 • Collegium Pharmaceutical Inc • Pharmaceutical preparations • Virginia

THIS INSTRUMENT AND THE RIGHTS AND OBLIGATIONS EVIDENCED HEREBY ARE SUBORDINATE IN THE MANNER AND TO THE EXTENT SET FORTH IN THAT CERTAIN SUBORDINATION AGREEMENT (THE “SUBORDINATION AGREEMENT”) DATED ON OR ABOUT NOVEMBER , 2014 BY AND AMONG SILICON VALLEY BANK, COLLEGIUM PHARMACEUTICAL, INC. AND THE HOLDER OF THIS INSTRUMENT AND HOLDERS OF OTHER INSTRUMENTS OF LIKE TENOR. THE HOLDER OF THIS INSTRUMENT AND BY ITS ACCEPTANCE HEREOF, SHALL BE BOUND BY THE PROVISIONS OF THE SUBORDINATION AGREEMENT. IN THE EVENT OF ANY INCONSISTENCY BETWEEN THIS NOTE AND THE SUBORDINATION AGREEMENT, THE TERMS OF THE SUBORDINATION AGREEMENT SHALL CONTROL.

COLLEGIUM PHARMACEUTICAL, INC. INDEMNIFICATION AGREEMENT
Indemnification Agreement • March 3rd, 2015 • Collegium Pharmaceutical Inc • Pharmaceutical preparations • Virginia

This Indemnification Agreement (“Agreement”) is effective as of , 2014 by and between Collegium Pharmaceutical, Inc., a Virginia corporation (the “Company”), and (“Indemnitee”).

780 DEDHAM STREET CANTON, MASSACHUSETTS OFFICE LEASE AGREEMENT BETWEEN 780 DEDHAM STREET HOLDINGS, LLC (“LANDLORD”) AND COLLEGIUM PHARMACEUTICAL, INC. (“TENANT”)
Office Lease Agreement • March 3rd, 2015 • Collegium Pharmaceutical Inc • Pharmaceutical preparations

This Office Lease Agreement (the “Lease”) is made and entered into as of the 28nd day of August, 2012, by and between 780 DEDHAM STREET HOLDINGS, LLC, a Maryland limited liability company (“Landlord”) and COLLEGIUM PHARMACEUTICAL, INC., a Delaware corporation (“Tenant”).

Collegium Pharmaceutical, Inc. Canton, MA 02021
Management Rights Agreement • March 3rd, 2015 • Collegium Pharmaceutical Inc • Pharmaceutical preparations

This letter will confirm our agreement that due to our ownership of shares of Preferred Stock of Collegium Pharmaceutical, Inc., a Virginia corporation (the “Company”), (the “Investor”) shall be entitled to the following contractual management rights, in addition to any rights to non-public financial information, inspection rights, and other rights specifically provided to all investors in the Company:

ASSUMPTION AND SECOND AMENDMENT TO LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • March 3rd, 2015 • Collegium Pharmaceutical Inc • Pharmaceutical preparations

This Assumption and Second Amendment to Loan and Security Agreement (this “Amendment”) is entered into this 12th day of August, 2014, by and between SILICON VALLEY BANK, a California corporation with a loan production office located at *** (“Bank”) and COLLEGIUM PHARMACEUTICAL, INC., a Virginia corporation with an office located at 780 Dedham Street, Suite 800, Canton, Massachusetts 02021 (“Borrower”).

LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • March 3rd, 2015 • Collegium Pharmaceutical Inc • Pharmaceutical preparations • California

This LOAN AND SECURITY AGREEMENT (this “Agreement”) is entered into as of the date set forth above (the “Effective Date”) by and between SILICON VALLEY BANK (“Bank”), and the borrower named above (“Borrower”). Capitalized terms used but not otherwise defined herein shall have the meanings given them on Schedule C. The parties agree as follows:

Collegium Pharmaceutical, Inc. Noncompetition, Confidentiality and Inventions Agreement
Noncompetition, Confidentiality and Inventions Agreement • March 3rd, 2015 • Collegium Pharmaceutical Inc • Pharmaceutical preparations

In consideration of my employment (“Employment”) by Collegium Pharmaceutical, Inc. or its subsidiaries (together, the “Company”), I, Michael Heffernan, agree as follows:

CONVERTIBLE NOTE PURCHASE AGREEMENT
Convertible Note Purchase Agreement • March 3rd, 2015 • Collegium Pharmaceutical Inc • Pharmaceutical preparations • Virginia

THIS CONVERTIBLE NOTE PURCHASE AGREEMENT (this “Agreement”) is dated as of November 14, 2014 by and among Collegium Pharmaceutical, Inc., a Virginia corporation (the “Company”), and the persons or entities listed as purchasers and set forth on the signature page hereof (the “Purchasers”).

Re: Employment Agreement
Employment Agreement • March 3rd, 2015 • Collegium Pharmaceutical Inc • Pharmaceutical preparations • Rhode Island

The letter agreement (“Agreement”) amends, restates and corrects the terms of your employment as President and Chief Executive Officer of Collegium Pharmaceutical, Inc (hereafter, “Collegium” or “Company”). This Agreement supersedes, cancels and terminates that certain employment agreement dated February 8, 2012 between yourself and the Company (the “Prior Agreement”).

COLLEGIUM PHARMACEUTICAL, INC. Series C Convertible Preferred Stock Purchase Agreement Dated as of August 27, 2013
Series C Convertible Preferred Stock Purchase Agreement • March 3rd, 2015 • Collegium Pharmaceutical Inc • Pharmaceutical preparations • Delaware

This Series C Convertible Preferred Stock Purchase Agreement (“Agreement”) dated as of August 27, 2013 is entered into by and among Collegium Pharmaceutical, Inc., a Delaware corporation (the “Company”), the individuals and entities listed on Schedule A hereto together with any individuals and entities who become parties to this Agreement by executing and delivering a financing signature page in the form of Schedule B hereto (each a “Purchaser” and collectively, the “Purchasers”). In consideration of the mutual promises and covenants contained in this Agreement, the parties hereto agree as follows:

FOURTH AMENDMENT TO LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • March 3rd, 2015 • Collegium Pharmaceutical Inc • Pharmaceutical preparations

This Fourth Amendment to Loan and Security Agreement (this “Amendment”) is entered into this31st day of October, 2014, by and between SILICON VALLEY BANK, a California corporation with a loan production office located at *** (“Bank”) and COLLEGIUM PHARMACEUTICAL, INC., a Virginia corporation with an office located at 780 Dedham Street, Suite 800, Canton, Massachusetts 02021 (“Borrower”).

COLLEGIUM PHARMACEUTICAL, INC. AMENDMENT NO. 1 TO THE SIXTH AMENDED AND RESTATED STOCKHOLDERS AGREEMENT
Stockholders Agreement • March 3rd, 2015 • Collegium Pharmaceutical Inc • Pharmaceutical preparations

This Amendment No. 1 dated as of January 29, 2015 (this “Amendment”) to the Sixth Amended and Restated Stockholders Agreement dated as of July 11, 2014 (the “Agreement”), is entered into by and among Collegium Pharmaceutical, Inc., a Virginia corporation (the “Company”), the Investors (as defined in the Agreement) and the Holders (as defined in the Agreement). Capitalized terms used but not defined herein shall have the meanings ascribed to them in the Agreement.

COLLEGIUM PHARMACEUTICAL, INC. Restricted Stock Award Agreement Under 2012 Stock Incentive Plan
Restricted Stock Award Agreement • March 3rd, 2015 • Collegium Pharmaceutical Inc • Pharmaceutical preparations • Delaware

THIS RESTRICTED STOCK AWARD AGREEMENT (this “Agreement”) is made as of June 13, 2012 (the “Grant Date”) by and between Collegium Pharmaceutical, Inc., a Delaware corporation (the “Company”), and Michael Heffernan (the “Participant”).

AGREEMENT AND PLAN OF MERGER
Merger Agreement • March 3rd, 2015 • Collegium Pharmaceutical Inc • Pharmaceutical preparations • Virginia

This Agreement and Plan of Merger (this “Agreement”) is made and entered into as of July 10, 2014, by and between Collegium Pharmaceutical, Inc., a Delaware corporation (“Parent”), and Collegium Pharmaceutical, Inc., a Virginia corporation and a wholly owned subsidiary of Parent (the “Company”).

COLLEGIUM PHARMACEUTICAL, INC. CONFIDENTIALITY AND INVENTIONS AGREEMENT
Confidentiality Agreement • March 3rd, 2015 • Collegium Pharmaceutical Inc • Pharmaceutical preparations • Massachusetts

In consideration of my employment (“Employment”) by Collegium Pharmaceutical, Inc. or its subsidiaries (together, the “Company”), I agree as follows:

COLLEGIUM PHARMACEUTICAL, INC. Series B Convertible Preferred Stock Purchase Agreement Dated as of February10, 2012
Series B Convertible Preferred Stock Purchase Agreement • March 3rd, 2015 • Collegium Pharmaceutical Inc • Pharmaceutical preparations • Delaware

This Series B Convertible Preferred Stock Purchase Agreement (“Agreement”) dated as of February 10, 2012 is entered into by and among Collegium Pharmaceutical, Inc., a Delaware corporation (the “Company”), and the individuals and entities listed on Schedule A hereto (each a “Purchaser” and collectively, the “Purchasers”). In consideration of the mutual promises and covenants contained in this Agreement, the parties hereto agree as follows:

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March 13, 2013
Employment Agreement • March 3rd, 2015 • Collegium Pharmaceutical Inc • Pharmaceutical preparations • Massachusetts

The letter agreement (“Agreement”) states the terms of your employment as Vice President, Business Development, for Collegium Pharmaceutical, Inc., a Delaware corporation (hereafter, “Collegium” or “Company”).

May 30, 2012
Employment Agreement • March 3rd, 2015 • Collegium Pharmaceutical Inc • Pharmaceutical preparations • Rhode Island

The letter agreement (“Agreement”) states the terms of your employment as Vice President, Clinical Development, for Collegium Pharmaceutical, Inc., a Delaware corporation (hereafter, “Collegium” or “Company”).

COLLEGIUM PHARMACEUTICAL, INC. SEVENTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT
Investor Rights Agreement • March 3rd, 2015 • Collegium Pharmaceutical Inc • Pharmaceutical preparations • Virginia

This Seventh Amended and Restated Investors Rights Agreement (the “Agreement”), dated as of July 11, 2014, is entered into by and among Collegium Pharmaceutical, Inc. (the “Company”), the individuals and entities listed on Exhibit A attached hereto (the “Investors”).

Contract
Warrant Agreement • March 3rd, 2015 • Collegium Pharmaceutical Inc • Pharmaceutical preparations • California

THIS WARRANT AND THE SHARES ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR ANY APPLICABLE STATE SECURITIES LAWS, AND, EXCEPT AND PURSUANT TO THE PROVISIONS OF ARTICLE 4 BELOW, MAY NOT BE OFFERED, SOLD OR OTHERWISE TRANSFERRED WITHOUT AN EFFECTIVE REGISTRATION THEREOF UNDER THE ACT AND ANY APPLICABLE STATE SECURITIES LAWS, OR PURSUANT TO RULE 144 OR AN EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE ACT AND ANY APPLICABLE STATE SECURITIES LAWS.

THIRD AMENDMENT TO LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • March 3rd, 2015 • Collegium Pharmaceutical Inc • Pharmaceutical preparations

This Third Amendment to Loan and Security Agreement (this “Amendment”) is entered into this 25th day of September, 2014, by and between SILICON VALLEY BANK, a California corporation with a loan production office located at *** (“Bank”) and COLLEGIUM PHARMACEUTICAL, INC., a Virginia corporation with an office located at 780 Dedham Street, Suite 800, Canton, Massachusetts 02021 (“Borrower”).

FIRST AMENDMENT TO LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • March 3rd, 2015 • Collegium Pharmaceutical Inc • Pharmaceutical preparations

This First Amendment to Loan and Security Agreement (this “Amendment”) is entered into this 31st day of January, 2014, by and between SILICON VALLEY BANK, a California corporation with a loan production office located at *** (“Bank”) and COLLEGIUM PHARMACEUTICAL, INC., a Delaware corporation with a loan production office located at 780 Dedham Street, Suite 800, Canton, Massachusetts 02021 (“Borrower”).

September 10, 2013
Employment Agreement • March 3rd, 2015 • Collegium Pharmaceutical Inc • Pharmaceutical preparations

Reference is made to that certain letter agreement dated June 13, 2012 between you and Collegium Pharmaceutical, Inc. (the “Company”) regarding the terms of your employment with the Company (the “Agreement”). Effective on the date hereof, this letter agreement (the “Amendment”) amends certain terms and conditions set forth in the Agreement as follows:

PREFERRED SHAREHOLDER AGREEMENT
Preferred Shareholder Agreement • March 3rd, 2015 • Collegium Pharmaceutical Inc • Pharmaceutical preparations • Virginia

This Preferred Shareholder Agreement (this “Agreement”) dated November 26, 2014 (“Effective Date”) is entered into by and among (a) Collegium Pharmaceutical, Inc., a Virginia corporation (the “Company”), (b) Boston Millennia Partners (as defined below), and (c) the Other Major Preferred Holders (as defined below).

COLLEGIUM PHARMACEUTICAL, INC. SIXTH AMENDED AND RESTATED STOCKHOLDERS AGREEMENT
Stockholders Agreement • March 3rd, 2015 • Collegium Pharmaceutical Inc • Pharmaceutical preparations • Virginia

THIS SIXTH AMENDED AND RESTATED STOCKHOLDERS AGREEMENT is made as of July 11, 2014 (this “Agreement”) by and among (i) Collegium Pharmaceutical, Inc. (the “Company”), (ii) holders of Common Stock or options to acquire Common Stock whose names are set forth on Schedule I hereto and each person who shall, after the date hereof, acquire shares of Common Stock and join in and become a party to this Agreement by executing and delivering to the Company an Instrument of Accession in the form of Exhibit A hereto (each a “Holder” and collectively as the “Holders”), and (iii) those persons and entities whose names are set forth on Schedule II hereto (each an “Investor” and collectively the “Investors”, and together with the Holders, collectively, the “Stockholders”).

AMENDMENT NO. 1 TO SERIES C CONVERTIBLE PREFERRED STOCK PURCHASE AGREEMENT
Series C Convertible Preferred Stock Purchase Agreement • March 3rd, 2015 • Collegium Pharmaceutical Inc • Pharmaceutical preparations

This Amendment No. 1 (this “Amendment”) dated as of September 24, 2013 amends that certain Series C Convertible Preferred Stock Purchase Agreement dated as of August 27, 2013 (the “Purchase Agreement”) by and among Collegium Pharmaceutical, Inc., a Delaware corporation (the “Company”), and the persons and entities listed on Schedule A attached thereto (the “Purchasers”). All capitalized terms used but not defined in this Amendment shall have the meanings assigned to such terms in the Purchase Agreement.

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