0000912282-08-001616 Sample Contracts

AMENDED AND RESTATED LICENSE AGREEMENT
License Agreement • November 10th, 2008 • Oncogenex Pharmaceuticals, Inc. • In vitro & in vivo diagnostic substances • British Columbia
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SECOND AMENDING AGREEMENT
License Agreement • November 10th, 2008 • Oncogenex Pharmaceuticals, Inc. • In vitro & in vivo diagnostic substances

THE UNIVERSITY OF BRITISH COLUMBIA, a corporation continued under the University Act of British Columbia and having its Industry Liaison offices at #103 – 6190 Agronomy Road, Vancouver, British Columbia, V6T 1Z3

EMPLOYMENT AMENDING AGREEMENT
Employment Agreement • November 10th, 2008 • Oncogenex Pharmaceuticals, Inc. • In vitro & in vivo diagnostic substances

ONCOGENEX TECHNOLOGIES INC. a corporation incorporated under the laws of Canada and having an office at Vancouver, British Columbia

EXECUTIVE TERMINATION AGREEMENT AND GENERAL RELEASE
Executive Termination Agreement • November 10th, 2008 • Oncogenex Pharmaceuticals, Inc. • In vitro & in vivo diagnostic substances • Washington

This EXECUTIVE TERMINATION AGREEMENT AND GENERAL RELEASE (“Executive Termination Agreement” or “Agreement”) is entered into between Alan Fuhrman (“Executive”) and Sonus Pharmaceuticals, Inc. (to be renamed “OncoGenex Pharmaceuticals, Inc.”) (referred to herein as “Sonus” or “Employer”).

EXECUTIVE TERMINATION AGREEMENT AND GENERAL RELEASE
Executive Termination Agreement • November 10th, 2008 • Oncogenex Pharmaceuticals, Inc. • In vitro & in vivo diagnostic substances • Washington

This EXECUTIVE TERMINATION AGREEMENT AND GENERAL RELEASE (“Executive Termination Agreement” or “Agreement”) is entered into between Michael A. Martino (“Executive”) and Sonus Pharmaceuticals, Inc. (to be renamed “OncoGenex Pharmaceuticals, Inc.”) (“Sonus” or “Employer”).

SECOND AMENDING AGREEMENT AND CONSENT
Second Amending Agreement • November 10th, 2008 • Oncogenex Pharmaceuticals, Inc. • In vitro & in vivo diagnostic substances

THE UNIVERSITY OF BRITISH COLUMBIA, a corporation continued under the University Act of British Columbia and having its Industry Liaison offices at #103 – 6190 Agronomy Road, Vancouver, British Columbia, V6T 1Z3

SECOND AMENDMENT TO
Arrangement Agreement • November 10th, 2008 • Oncogenex Pharmaceuticals, Inc. • In vitro & in vivo diagnostic substances

This Second Amendment to Arrangement Agreement (this "Amendment") is made and entered into as of August 15, 2008, by and between Sonus Pharmaceuticals, Inc. a Delaware corporation ("Sonus"), and OncoGenex Technologies Inc., a corporation organized pursuant to the Canada Business Corporations Act ("OncoGenex"). Sonus and OncoGenex are sometimes referred to herein as the "Parties."

FIRST AMENDMENT TO
Arrangement Agreement • November 10th, 2008 • Oncogenex Pharmaceuticals, Inc. • In vitro & in vivo diagnostic substances

This First Amendment to Arrangement Agreement (this “Amendment”) is made and entered into as of August 11, 2008, by and between Sonus Pharmaceuticals, Inc. a Delaware corporation (“Sonus”), and OncoGenex Technologies Inc., a corporation organized pursuant to the Canada Business Corporations Act (“OncoGenex”). Sonus and OncoGenex are sometimes referred to herein as the “Parties.”

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