0000927016-03-002448 Sample Contracts

TERMINATION AND TRANSFER AGREEMENT
Termination and Transfer Agreement • May 7th, 2003 • Curis Inc • Biological products, (no disgnostic substances) • Delaware

WHEREAS Aegera and Curis are parties to a license and collaboration agreement dated as of January 5, 2001, as amended by a letter dated March 20, 2001 (collectively, the “License Agreement”), whereby the parties agreed to cooperate with each other in order to develop potential therapeutics and diagnostics from stem cell technologies;

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Re: First Amendment of Loan Agreement
Security Agreement • May 7th, 2003 • Curis Inc • Biological products, (no disgnostic substances) • Massachusetts

Reference is made to that certain Loan Agreement dated June 14, 2002 (together with all exhibits thereto, the “Agreement”) between Curis, Inc. (the “Borrower”) and Boston Private Bank & Trust Company (the “Bank”). The Agreement is being amended to reflect a new financing arrangement between the Bank and the Borrower, namely, the conversion of the Term Loan (as defined in the Agreement) into a Line of Credit and accordingly, the Term Note (as defined in the Agreement) into a Secured Revolving Time Note. Notwithstanding the provisions of the Agreement, the Agreement is hereby amended, as of the date hereof, as follows:

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